Caspase-8多克隆抗體

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產(chǎn)品英文名稱(chēng)	Caspase-8 Polyclonal Antibody
免疫原	合成多肽：人源蛋白Caspase-8，非磷酸化多肽，中心氨基酸為S347.
宿主	兔
反應性	人, 大鼠, 小鼠
應用	ELISA, IF, IHC-P, WB
實(shí)驗建議	最佳的工作稀釋比例需要客戶(hù)摸索優(yōu)化。建議的起始嘗試的稀釋比為：WB：1:500-1:2000，IHC-p：1:100-1:300，ELISA：1:5000。尚未在其他應用中測試。
克隆性	多克隆
純化工藝	使用表位特異性的免疫原，通過(guò)親和層析，從兔抗血清中親和純化抗體。

產(chǎn)品形式	液體溶液
濃度	1 mg/ml
儲存緩沖液	含有50％甘油，0.5％BSA和0.02％疊氮化鈉的PBS緩沖液。
保存建議	自發(fā)貨之日起，-20°C可穩定保存1年。為最大限度的避免損失，請在打開(kāi)管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復凍融。
運輸條件	藍冰運輸
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類(lèi)或臨床診斷。我們產(chǎn)品所推薦應用，不是建議使用我們的產(chǎn)品去違反任何專(zhuān)利或許可證。對于使用本產(chǎn)品可能發(fā)生的專(zhuān)利侵權或其他違規行為，我們不承擔任何責任。

背景	CASP8 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
基因ID	841
別名	CASP8; MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH
其它	該抗體可檢測內源蛋白
蛋白質(zhì)ID	Q14790
目標條帶分子量（KD)	55