貨號 | 品牌 | CAS | 規格 | 銷(xiāo)售價(jià)(RMB) | 折扣價(jià)(RMB) | 備注 | 數量 |
ABL1130-200μL | Abbkine | 無(wú) | 200μL | 1798 | 1798 | 無(wú) | |
ABL1130-50μL | Abbkine | 無(wú) | 50μL | 606 | 606 | 無(wú) |
產(chǎn)品英文名稱(chēng) | Anti-Cyclophilin B Monoclonal Antibody (7B2) |
免疫原 | 合成多肽 |
宿主 | 小鼠 |
反應性 | 人, 大鼠, 小鼠 |
應用 | IF, IHC-P, WB |
實(shí)驗建議 | 最佳的工作稀釋比例需要客戶(hù)摸索優(yōu)化。建議的起始嘗試的稀釋比為:WB:1:1000-1:2000,IHC-P:1:50-1:300,IF:1:50-1:200。 |
克隆性 | 單克隆 |
純化工藝 | 通過(guò)使用特異性免疫原的親和層析,從小鼠腹水中純化抗體。 |
產(chǎn)品形式 | 液體溶液 |
儲存緩沖液 | PBS緩沖液(pH 7.4),含有0.5%BSA(穩定劑),0.02%疊氮化鈉(防腐劑)和50%甘油。 |
保存建議 | 自發(fā)貨之日起,-20°C可穩定保存1年。為最大限度的避免損失,請在打開(kāi)管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復凍融。 |
運輸條件 | 藍冰運輸 |
警告 | 本文列出的產(chǎn)品僅供研究使用,不適用于人類(lèi)或臨床診斷。我們產(chǎn)品所推薦應用,不是建議使用我們的產(chǎn)品去違反任何專(zhuān)利或許可證。對于使用本產(chǎn)品可能發(fā)生的專(zhuān)利侵權或其他違規行為,我們不承擔任何責任。 |
背景 | Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. |
基因ID | 5479 |
別名 | PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
蛋白質(zhì)ID | P23284 |
目標條帶分子量(KD) | 21 |
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